TCIPF - Clinical: T- and B-Cell Quantitation and Lymphocyte Proliferation to Antigens and Mitogens Panel

Test Catalog

Test ID: TCIPF    
T- and B-Cell Quantitation and Lymphocyte Proliferation to Antigens and Mitogens Panel

Useful For Suggests clinical disorders or settings where the test may be helpful

Assessing antigen-specific T-cell responses, global T-cell function, and quantitating lymphocyte subsets in a single orderable test.

 

This panel is most helpful when evaluating patients with immunodeficiencies, where quantitative decreases in T cells can lead to reduced functional antigen and/or mitogen responses.

 

See individual test IDs for additional information.

Testing Algorithm Delineates situation(s) when tests are added to the initial order. This includes reflex and additional tests.

If insufficient peripheral blood mononuclear cells (PBMCs) are isolated from the patient's sample due to low WBC counts or specimen volume received, selected dilutions or stimulants may not be tested at the discretion of the laboratory to ensure the most reliable results. Testing with 1 stimulant will always be performed. When adequate specimen is available for both stimulants to be tested, an additional test code will be reflexed and billed separately.

 

When multiple specimen types are required to perform a panel of tests, the laboratory will perform the tests for which the appropriate specimen type was received and the laboratory will cancel those for which the appropriate specimen was not received. Be advised that this may change the degree of interpretation received with the report.

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

See Individual Test IDs

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

The appropriate age-related reference values will be provided on the report.

Interpretation Provides information to assist in interpretation of the test results

Since the presence of lymphopenia, particularly in the T-cell compartment, can reduce the magnitude of the proliferative response to both mitogens and antigens, it is helpful to perform simultaneous numerical evaluation of lymphocyte subsets to aid in interpretation of the functional (proliferation) data.

 

See individual test IDs for additional information.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

There is no clinical utility to assessing antigen responses in infants less than 3 months old due to limited antigen exposure and vaccination. The only exception would be infants who develop Candidiasis prior to 3 months of age. This test is not intended for assessment of maternal engraftment.

 

See individual test IDs for additional information.

Clinical Reference Provides recommendations for further in-depth reading of a clinical nature

See individual test IDs