FIGA - Clinical: Anti-IgA

Test Catalog

Test Name

Test ID: FIGA    
Anti-IgA

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

For the evaluation of patients with recurrent infection for the possibility of IgA deficiency (IgAD). Patients with IgA deficiency may develop antibodies against IgA that make them susceptible to adverse reactions to blood products including intravenous immunoglobulin.

 

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

<99 U/mL

 

Patients with IgG antibodies against IgA may suffer from anaphylactoid reactions when given IVIG that contains small quantities of IgA. In one study (Clinical Immunology 2007; 122:156) five out of eight patients with IgG anti-IgA antibodies developed anaphylactoid reactions when IVIG was administered.

 

Clinical Reference Provides recommendations for further in-depth reading of a clinical nature

Hammarstrom L, Vorechovsky I, Webster D. Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID). Clin Exp Immunol. 2000; 120:225-231.

- Burrows D, Cooper MD: IgA Deficiency. Adv Immunol 1997; 65:245-276.

- Aghamohammadi A, Mohammadi J, Parvaneh N, Rezael N, Moin M, Espanol T. and Hammarstrom L. Progression of Selective IgA

Deficiency to Common Variable Immunodeficiency. Int Arch Allergy Immunol 2008;147:87-92.

Horn J, Thon V, Bartonkova D, Salzer U, warnatz K, Schlesier M, Peter H, and Grimbacher B. Anti-IgA antibodies in Common

Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy. Clin Immunol 2007;122:156-162.