|Values are valid only on day of printing.|
To determine the co-receptor tropism (CCR5, CXCR4, or dual/mixed) of a patient's HIV-1 strain for selection of CCR5 co-receptor antagonist therapy, when patient's HIV-1 viral load is <1,000 copies/mL.
Trofile DNA Viral Classification
CCR5 Tropic (R5) HIV-1:
Virus uses CCR5 to enter CD4+ cells.
CXCR4 Tropic (X4) HIV-1:
Virus uses CXCR4 to enter CD4+ cells.
DUAL /MIXED Tropic (D/M) HIV-1:
Dual-tropic viruses can use either CXCR4 or CCR5 to enter CD4+ cells. Mixed-tropic populations contain viruses with 2 or more tropisms.
Co-receptor tropism could not be determined. Common causes of nonreportable results are reduced viral fitness or compromised sample handling. Please note that Trofile DNA sample collection and handling instructions differ from Trofile and other Monogram assays.
Trofile uses the complete gp160 coding region of the HIV-1 envelope protein ensuring that all of the determinants of tropism are tested. Subtype is determined based on the HIV-1 gp41 envelope region.