Unit Code 5363:
X-Ray Microanalysis
Useful For
Useful for idenfitying elements within biological specimens. It
is the only technique that provides an in situ means of
identifying elements within precise localized areas of thin
sections.
Clinical Information
X-ray microanalysis is based on the principle that atoms, when
struck by a high energy electron beam, yields x-rays whose energy
is characteristic of those atoms. This, when coupled with an electron
microscope, allows for elemental as well as morphological analysis
of tissue and cell components.
Reference Values
This request will be processed as a consultation. Appropriate
procedures will be performed and an interpretation provided.
Interpretation
Qualitative analysis can be performed simultaneously for all
elements in the periodic chart from boron (Z=4) through uranium
(Z=92).
Semiquantitative analysis may be possible in some cases.
Cautions
For accurate interpretation of data, proper specimen fixation
is critical.
The introduction of other elements may clutter the spectrum with
numerous unnecessary peaks making interpretation very difficult.
Not useful for identification of trace elements in a large volume
Clinical Reference
Ghadially FN: Invited review. The technique and scope of
electron-probe x-ray analysis in pathology. Pathology
11:95-110, 1979.
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