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Determining HLA Class II compatibility on specimens from bone marrow and solid organ transplant candidates and their donors
Human leukocyte antigens (HLA) are regulators of the immune response that play a key role in transplantation.
Sequence-specific oligonucleotides are designed to provide low-to-medium resolution for HLA Class II (DR and DQ) typing. Low-to-medium resolution defines the typing at the antigen level. This is in contrast to high-resolution typing, which defines typing at the allele (molecular) level and is used primarily for typing donor-recipient pairs for unrelated bone marrow transplantation.
Interpretation depends on the rationale for ordering the test. Assessments of acceptable donor/recipient matches are made on a case-by-case basis.
No significant cautionary statements
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