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Unit Code 81596:
Glutamic Acid Decarboxylase (GAD65) Antibody Assay, Serum

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Useful For

Assessing susceptibility to autoimmune (type 1, insulin-dependent)

diabetes mellitus and related endocrine disorders (eg, thyroiditis and

pernicious anemia). Titers generally <20 nmol/L.

 

Distinguishing between patients with type 1 and type 2 diabetes.

Assays for gastric parietal cell, thyroglobulin, and thyroid peroxidase

antibodies, complement GAD65 antibody in this context. Titers

generally <20 nmol/L.

 

Confirming a diagnosis of stiff-man syndrome, autoimmune encephalitis,

cerebellitis, brain stem encephalitis, myelitis. Titers generally >20 nmol/L.

 

 

Confirming susceptibility to organ-specific neurological disorders

(eg, myasthenia gravis, Lambert-Eaton syndrome). Titers generally

<20 nmol/L.

Special Instructions and Forms

• Paraneoplastic Evaluation Algorithm 

Method Name

Radioimmunoassay (RIA)
 
See "Paraneoplastic Evaluation Algorithm" in
Special Instructions.

Reporting Name

GAD65 Ab Assay, S

Ordering Mnemonic

GAD65

Aliases

64K Antibody

Anti-GAD Antibodies

Anti-Glutamic Acid Decarboxylase Ab

Beta Cell Antibody

GAD65 Antibody Assay

Glutamate Decarboxylase Antibodies

Islet Cell Antibody (Mayo Alternative GAD65)

Pancreatic Islet Cell Ab

Stiffman Syndrome

Key