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Interpretive Handbook

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Test 90170 :
17-Hydroxy Progesterone, Urine

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

17-Hydroxy Progesterone is a steroid derived primary from enzymatic

metabolism of Progesterone and 17-Hydroxy Pregnenolone. It is converted

enzymatically to Androstenedione and 11-Deoxycortisol. It is produced

in both the gonads and adrenal glands. It is excreted into the urine in

conjugated and unconjugated forms of 17-Hydroxy Progesterone and

as Pregnanetriol. This assay measures the total of the conjugated and

unconjugated forms. It is stimulated by ACTH and suppressed by

Dexamethasone. Levels of urine 17-Hydroxy Progesterone are greatly

increased in patients with Polycystic Ovarian Disease and Congenital

Adrenal Hyperplasia and show exaggerated responses to ACTH in

these cases. 17-Hydroxy Progesterone is the marker steroid for

determining cases of 21a-Hydroxylase Deficient Congenital Adrenal

Hyperplasia. Urine levels are frequently elevated in patients with

idiopathic hirsutism.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Pediatric Reference Ranges:

Newborns and Infants:

3 days to 1 year:  Up to 50 ng/24 hrs

 

Children: 1 - 8 years:  Up to 300 ng/24 hrs

 

Adult Reference Ranges:

Male:  Up to 2.0 ug/24 hrs.

 

Female: Up to 4.5 ug/24 hrs.

 

Test Performed by: Inter Science Institute

                                      944 West Hyde Park Blvd.

                                      Inglewood, CA 90302


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