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Interpretive Handbook

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Test 62488 :
Yes Associated Protein (YAP), Immunostain

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Yes-associated protein (YAP) is a downstream regulatory target in the Hippo signaling pathway that is upregulated in sonic hedgehog-associated medulloblastomas and medulloblastomas with activation of the Wnt signaling pathway and is expressed on lung, placenta, prostate, ovary, and testis.

Useful For Suggests clinical disorders or settings where the test may be helpful

Identification and differentiation of medulloblastomas

Interpretation Provides information to assist in interpretation of the test results

This test will be processed as a pathology consultation. An interpretation will be provided.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

This request will be processed as a consultation. An interpretation will be provided.

Clinical References Provides recommendations for further in-depth reading of a clinical nature

1. Ellison DW, Dalton J, Kocak M, et al: Medulloblastoma clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups. Acta Neuropathol 2011;121:381-396

2. Northcott PA, Korshunov A, Witt H, et al: Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 2011 Apr 10;29(11):1408-1414

3. Thompson MC, Fuller C, Hogg TL, et al: Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol 2006;24:1924-931