Thyroid Transcription Factor (8G7G3/1), Immunostain
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Thyroid transcription factor 1 is a nuclear protein expressed in thyroid follicular cells, type II pneumocytes, and a subset of bronchial cells. Given its relative specificity for cells of thyroid or lung origin, this immunostain is often included in a panel to identify the primary site for carcinomas of unknown origin.
Identification of thyroid or lung cells as the primary tumor site in carcinomas of unknown origin
This test will be processed as a pathology consultation. An interpretation will be provided.
Clinical References Provides recommendations for further in-depth reading of a clinical nature
1. Comperat E, Zhang F, Perrotin C, et al: Variable sensitivity and specificity of TTF-1 antibodies in lung metastatic adenocarcinoma of colorectal origin. Mod Pathol 2005;18:1371-1376
2. Penman D, Downie I, Roberts F: Positive immunostaining for thyroid transcription factor-1 in primary and metastatic colonic adenocarcinoma: a note of caution. J Clin Pathol 2006;59:663-664
3. Katoh R, Kawaoi A, Miyagi E, et al: Thyroid Transcription Factor-1 in Normal, Hyperplastic, and Neoplastic Follicular Thyroid Cells Examined by Immunohistochemistry and Nonradioactive In Situ Hybridization. Mod Pathol 2000;13(5):570-576