Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Secretin is a 27 amino acid basic peptide produced by S cells and
released by acid delivered into the duodenum. Secretin is released
into the blood when duodenal pH drops below 4. Secretin shares
structural similarity with Glucagon, Gastric Inhibitory Polypeptide,
Vasoactive Intestinal Polypeptide, PHIM, and Growth Hormone-
Releasing Hormone. Secretin is a potent stimulus for bicarbonate
secretion. Secretin also stimulates secretion of bile, release of Insulin,
and release of Gastric Pepsin in the stomach. Secretin inhibits Glucagon
release, intestinal motility, and prevents the uptake of water and sodium
ions by the intestine. In normal patients, Secretin has little effect on Gastrin
levels, but stimulates Gastrin greatly in Zollinger-Ellison patients. Secretin
is also elevated in Zollinger-Ellison patients and in patients with duodenal
ulcer. Secretin levels are low in patients with pernicious anemia and
achlorhydria. Secretin secretion can be suppressed by Somatostatin,
Cimetidine, and Methionine-Enkephalin.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
12 - 75 pg/mL (mean=25)
This test was developed and its performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.