Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Somatostatin is a cyclic peptide originally isolated from sheep hypothalami
and shown to inhibit the release of Growth Hormone. Somatostatin is present
primarily in three main forms: a 14 amino acid peptide, a 28 amino acid peptide
(Big Somatostatin), and a 12,000 molecular weight Pro-Somatostatin. This
assay measures only the 14 amino acid form of Somatostatin. All three forms
of Somatostatin have similar biological properties and overall potencies.
Somatostatin is a physiological regulator of islet cell and gastrointestinal functions,
and is a suppressor of many pituitary hormones including Growth Hormone, Prolactin,
and Thyrotropin (TSH). Somatostatin levels are often elevated in diabetics, but the
levels return to normal upon correction of the hormonal and metabolic deficiencies
present. In many cases of APUDomas including VIPoma, Insulinoma, Glucagonoma,
and Gastrinoma, elevated levels of Somatostatin are found.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Up to 25 pg/ml
This test was developed and its performance characteristics
determined by Inter Science Institute. It has not been cleared or
approved by the US Food and Drug Administration. The FDA
has determined that such clearance or approval is not necessary.