Respiratory Syncytial Virus (RSV) Antibodies, IgG and IgM (Separate Determinations), Serum
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Respiratory syncytial virus (RSV) is an important cause of human respiratory infection. It strikes most frequently and severely in the very young and is a common cause of bronchiolitis, pneumonia, or croup in young infants. Infections in older children and adults tend to be milder and to involve the upper respiratory tract. RSV infections are seasonal, from late fall to spring, and often occur in epidemic form.
Aiding in the diagnosis of a recent respiratory syncytial virus infection
The presence of IgM class antibodies or a 4-fold or greater rise in paired sera IgG titer indicates recent infection.
The presence of demonstrable IgG generally indicates past exposure and immunity.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
For low IgG antibody levels with no demonstrable IgM, it is recommended that a convalescent specimen be drawn in 2 to 4 weeks.
Not useful for diagnosis from spinal fluid.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
The presence of IgM class antibodies or a 4-fold or greater rise in paired sera IgG titer indicates recent infection. The presence of demonstrable IgG generally indicates past exposure and immunity.
Clinical References Provides recommendations for further in-depth reading of a clinical nature
Tristram DA, Welliver RC: Respiratory syncytial virus. In Manual of Clinical Microbiology. 7th edition. Edited by PR Murray, EJ Baron, MA Pfaller, et al. Washington, DC, American Society for Microbiology, 1999, pp 942-950