Prealbumin (PAB), Serum
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Prealbumin is synthesized in the liver and acts as a binding protein for thyroxine and retinol-binding protein.
The serum concentration of prealbumin reflects the synthesis capacity of the liver and is markedly diminished in malnutrition and other conditions.
Due to its short half-life of approximately 2 days, prealbumin can be used for monitoring the nutritional status and efficacy of parenteral nutrition.
Assessing nutritional status, especially in monitoring the response to nutritional support in the acutely ill patient
Values of 0 to 5 mg/dL, 5 to 10 mg/dL, and 10 to 15 mg/dL indicate severe, moderate, and mild protein depletion.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
No significant cautionary statements
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Clinical References Provides recommendations for further in-depth reading of a clinical nature
1. Haider M, Haider SQ: Assessment of protein-calorie malnutrition. Clin Chem 1984;30:1286-1299
2. Grant JP, Custer PB, Thurlow J: Current techniques of nutritional assessment. Surg Clin North Am 1981;61:437-463
3. Bernstein LH, Leukhardt-Fairfield CJ, Pleban W, et al: Usefulness of data on albumin and prealbumin concentrations in determining effectiveness of nutritional support. Clin Chem 1989;35:271-274
4. Kanakoudi F, Drossou V, Tzimouli V, et al: Serum concentrations of 10 acute-phase proteins in healthy term and pre-term infants from birth to age 6 months. Clin Chem 1995;41:605-608