Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
p40 is an antibody that recognizes the deltaNp63 isoform of p63. This isoform may exert an oncogenic effect and is selectively expressed in squamous cell carcinoma.
Diagnosis and classification of carcinomas and lymphomas
This test will be processed as a pathology consultation. An interpretation will be provided.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
This test is not an orderable test. Order test 70016 / Hematopathology Consultation, Wet Tissue or 70012 / Pathology Consultation. The consultant will determine the need for special stains.
This request will be processed as a consultation. An interpretive report will be provided.
Clinical References Provides recommendations for further in-depth reading of a clinical nature
1. Travis WD, Brambilla E, Noguchi M, et al: Diagnosis of Lung Cancer in Small Biopsies and Cytology: Implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification. Arch Pathol Lab Med 2012 Sep 12. (Epub ahead of print)
2. Nonaka D. A study of deltaNp63 expression in lung non-small cell carcinomas. Am J Surg Pathol 2012;36(6):895-899
3. Pelosi G, Fabbri A, Bianchi F, et al: DeltaNp63 (p40) and thyroid transcription factor-1 immunoreactivity on small biopsies or cellblocks for typing non-small cell lung cancer: a novel two-hit, sparing-material approach. J Thorac Oncol 2012;7(2):281-290
4. Bishop JA, Teruya-Feldstein J, Westra WH et al: p40 (ΔNp63) is superior to p63 for the diagnosis of pulmonary squamous cell carcinoma. Mod Pathol 2012;25(3):405-415
5. Geddert H, Kiel S, Heep HJ, et al: The role of p63 and deltaNp63 (p40) protein expression and gene amplification in esophageal carcinogenesis. Hum Pathol 2003;34(9):850-856