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Interpretive Handbook

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Test 5341 :
Peripheral Nerve Pathology Consultation

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Nerve biopsies provide information about nerve fibers and the interstitum of the nerve. Neuropathic abnormalities include decreased density of myelinated fibers, segmental demyelination, and axonal degeneration. Some possible interstitial abnormalities that affect nerves include necrotizing vasculitis and amyloidosis.

Useful For Suggests clinical disorders or settings where the test may be helpful

Evaluating diseases of the nerve and disorders that affect nerve function


This consultation is for slides or fixed tissue

Interpretation Provides information to assist in interpretation of the test results

The clinical and neurological history is reviewed with the interpretation of the biopsy.


The histologic slides, special stains, and history, along with the physician's report are correlated by a neuropathologist. An interpretive report will be provided.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Poor fixation, orientation, and improper handling of the nerve tissue may hinder the neuropathologist's interpretation of the biopsy. See Directions for Preparing Nerve Biopsy Specimens for Study at Mayo in Special Instructions. Kits containing the proper tissue fixatives and buffers are available upon request.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

A consultative report will be provided.