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Interpretive Handbook

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Test 90156:
Neurotensin

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Neurotensin is a 13 amino acid peptide produced primarily by endocrine

cells of the ileal mucosa. Physiological actions of Neurotensin include

hypertension, vasodilation, hyperglycemia, and inhibition of gastric motility.

Its C-terminus is similar to Angiotensin I. It is a potent analgesic affecting

hypothermia, muscle relaxation, and decreased motor activity. Pancreatic

Polypeptide secretion is strongly stimulated by Neurotensin. Neurotensin

appears to cause the release of Luteinizing Hormone-Releasing Hormone

and Corticotropin Releasing Hormone effecting the release of Luteinizing

Hormone, Follicle Stimulating Hormone, and ACTH but not Thyroid

Stimulating Hormone or Growth Hormone. Neurotensin also stimulates

pancreatic bicarbonate and intestinal secretion. Neurotensin levels are

stimulated by food and Bombesin. Elevated levels have been found in

pancreatic endocrine tumors, Oat Cell, Squamous, and Adeno Carcinomas.

Elevated levels have been found to cause watery diarrhea.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

50-100 pg/mL

 

Test Performed By:  Inter Science Inst

                               944 West Hyde Park

                               Inglewood, CA  90302