MyoMarker Panel 2
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
1. Anti-Jo 1 Abs are found in subset of myositis patients characterized by interstitial lung disease, systemic polyarthritis, Raynaud’s Phenomena, fever and Mechanic’s Hand (anti-synthetase syndrome).
2. Anti-Jo 1 appears to be a marker for interstitial lung disease in polymyositis.
3. The anti-PM/Scl-100 antibody is associated with younger age, calcinosis and has lower rates of gastrointestinal symptoms, ILD and pulmonary hypertension. There is also evidence of a possibly better survival compared to the presence of either anti-PM/Scl-75 or anti-Scl-70 antibodies.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Mi-2, PL-12, PL-7, EJ, OJ, SRP, Ku, U2 snRNP
Reference Range: Negative
Anti-PM/Scl-100 Ab, Anti-Jo-1 Ab
Reference Range: <20
Negative: <20 units
Weak Positive: 20 - 39 units
Moderate Positive: 40 - 80 units
Strong Positive: >80 units