Motilin, Plasma or Serum
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Motilin is a 22 amino acid peptide produced primarily by the enterochromaffin
cells (EC2 or M cells) in the intestine, duodenum and the jejunum. It is
absent from the stomach and colon. Motilin accelerates gastric emptying
and colonic motor activity. Motilin also stimulates the feeding response.
It has no structural similarities with other gastrointestinal peptides. Motilin
secretion can be stimulated by acid and a fat-rich meal. Motilin can
increase the secretion of pepsin and causes increased intra-gastric
pressure. Motilin also stimulates lower esophageal sphincter contraction.
Motilin levels are suppressed by Calcitonin. Motilin has a short half-life
of approximately five minutes.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Up to 446 pg/mL
This test was developed and its performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.
Test Performed by: Inter Science Institute
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