Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Iodine is an essential element that is required for thyroid hormone production. The measurement of iodine serves as an index of adequate dietary iodine intake and iodine overload, particularly from iodine-containing drugs such as amiodarone.
Determination of iodine overload
Monitoring iodine levels in individuals taking iodine-containing drugs
Values between 80 ng/mL and 250 ng/mL have been reported to indicate hyperthyroidism.
Values >250 ng/mL may indicate iodine overload.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
There are no known analytical interferences with this procedure.
Administration of iodine-containing contrast media will yield elevated results.
Disinfectants (such as Betadine) that contain iodine should not be used during venipuncture.
High concentrations of gadolinium are known to interfere with most metals tests. If gadolinium-containing contrast media has been administered, a specimen should not be collected for 48 hours.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Clinical References Provides recommendations for further in-depth reading of a clinical nature
Allain P, Berre S, Krari N, et al: Use of plasma iodine assay for diagnosing thyroid disorders. J Clin Pathol 1993 May;46(5):453-455