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The assessment of glomerular filtration rate (GFR) is an important parameter of renal function utilized by clinicians in the care of patients with varying renal diseases, and for clinical research when precise assessment of renal function is necessary. The GFR is the sum of all the filtration rates of the individual nephrons within the kidney and, as such, reflects the number of functioning nephrons.
Determining glomerular filtration rate
Low glomerular filtration rate (GFR) values indicate abnormal renal function, which may be either reversible/transient or irreversible/permanent. GFR tends to decline with age.
A theoretical complication to injection of iodinated contrast media (one that has not been observed clinically to date) is the transient suppression of thyroid function in premature and newborn infants. Therefore, a sensitive thyrotropin test is suggested approximately 2 to 3 weeks after an iohexol clearance in that age group.
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3. Schwartz GJ, Abraham AG, Furth SL, et al: Optimizing iohexol plasma disappearance curves to measure the glomerular filtration rate in children with chronic kidney disease. Kidney Int 2010;77:65-71