|Values are valid only on day of printing.|
Erythrocyte glucose phosphate isomerase (GPI) deficiency has been reported as a cause of chronic hemolysis in numerous cases. Inheritance is autosomal recessive. Hemolytic disease of the newborn is a common presenting manifestation of GPI deficiency.
A second-order test in the evaluation of individuals with chronic hemolysis
Glucose phosphate isomerase (GPI) deficiency causes a moderately severe anemia. GPI values can be 25% of normal.
Increased GPI activity may be seen when young red blood cells are being produced in response to the anemia (reticulocytosis) or in the case of a newborn.
No significant cautionary statements
> or =12 months: 39.3-57.7 U/g Hb
Reference values have not been established for patients who are <12 months of age.
Fairbanks VF, Klee GG: Biochemical aspects of hematology. In Tietz Textbook of Clinical Chemistry. Third Edition. Edited by CA Burtis, ER Ashwood, Philadelphia, WB Saunders Company, 1999, pp 1642-1646