Interpretive Handbook
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Test 9158:
Glucose Phosphate Isomerase, Erythrocytes
Clinical Information 
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Erythrocyte glucose phosphate isomerase (GPI) deficiency has been reported as a cause of chronic hemolysis in numerous cases. Inheritance is autosomal recessive. Hemolytic disease of the newborn is a common presenting manifestation of GPI deficiency.
Useful For Suggests clinical disorders or settings where the test may be helpful
A second-order test in the evaluation of individuals with chronic hemolysis
Interpretation Provides information to assist in interpretation of the test results
Glucose phosphate isomerase (GPI) deficiency causes a moderately severe anemia. GPI values can be 25% of normal.
Increased GPI activity may be seen when young red blood cells are being produced in response to the anemia (reticulocytosis) or in the case of a newborn.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
No significant cautionary statements
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
39.3-57.7 U/g hemoglobin
Clinical References Provides recommendations for further in-depth reading of a clinical nature
Fairbanks VF, Klee GG: Biochemical aspects of hematology. In Tietz Textbook of Clinical Chemistry. Third Edition. Edited by CA Burtis, ER Ashwood, Philadelphia, WB Saunders Company, 1999, pp 1642-1646
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