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Interpretive Handbook

Test 90171 :
Gastric Inhibitory Polypeptide (GIP)

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Gastric Inhibitory Peptide is a 43 amino acid peptide structurally related to Glucagon and Secretin and is found in the mucosa of upper intestine produced by K cells. GIP was originally detected as a factor inhibiting the secretion of gastric acid and Gastrin secretion. Its major action has now been determined to be a potent stimulant of B cells to release Insulin and is also known as Glucose-Dependent Insulinotropic Peptide. Exaggerated increases in GIP are noted after glucose administration to patients with Pancreatitis. This increase is also seen in patients with Diabetes Mellitus. GIP levels are decreased by Calcitonin.  Elevated levels are present in cases of Verner-Morrison Syndrome.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Fasting:  Up to 50 pg/ml

Postprandial:  110 - 720 pg/ml