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Interpretive Handbook

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Test 8976:
Granulocyte Antibodies, Serum

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Granulocyte antibodies are induced by pregnancy or prior transfusion and are associated with febrile, nonhemolytic transfusion reactions. Patients who have been immunized by previous transfusions, pregnancies, or allografts frequently experience febrile, nonhemolytic transfusion reactions which must be distinguished from hemolysis before further transfusions can be safely administered. Granulocyte antibodies may also be present in autoimmune neutropenia.

Useful For Suggests clinical disorders or settings where the test may be helpful

The work-up of individuals having febrile, nonhemolytic transfusion reactions

 

The detection of individuals with autoimmune neutropenia

Interpretation Provides information to assist in interpretation of the test results

A positive result in an individual being worked up for a febrile transfusion reaction indicates the need for leukocyte-poor (filtered) red blood cells.

 

This test cannot distinguish between allo- and autoantibodies

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Not useful for diagnosis of neutropenia caused by marrow suppression by drugs or tumors

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Not applicable

Clinical References Provides recommendations for further in-depth reading of a clinical nature

Verheugt FW, von dem Borne AE, Decary F, Engelfreit CP: The detection of granulocyte alloantibodies with an indirect immunofluorescence test. Br J Haematol 1997;36:533-534