GRB2-Associated Binding Protein 1 (GAB1), Immunostain
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
GAB1 (growth factor receptor bound protein 2-associated protein 1) is an adapter protein that is involved in growth, transformation, and apoptosis. GAB1 can be used with a panel of immunohistochemical markers in the classification of medulloblastomas into SHH (sonic hedgehog), WNT (wingless-type murine mammary tumor), or non-SHH/WNT subgroups.
Identification and differentiation of medulloblastomas
This test will be processed as a pathology consultation. An interpretation will be provided.
Clinical References Provides recommendations for further in-depth reading of a clinical nature
1. Ellison DW, Dalton J, Kocak M, et al: Medulloblastoma clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups. Acta Neuropathol 2011;121:381-396
2. Northcott PA, Korshunov A, Witt H, et al: Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 2011 Apr 10;29(11):1408-1414
3. Thompson MC, Fuller C, Hogg TL, et al: Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol 2006;24:1924-931