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Interpretive Handbook

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Test 62490 :
GRB2-Associated Binding Protein 1 (GAB1), Immunostain

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

GAB1 (growth factor receptor bound protein 2-associated protein 1) is an adapter protein that is involved in growth, transformation, and apoptosis. GAB1 can be used with a panel of immunohistochemical markers in the classification of medulloblastomas into SHH (sonic hedgehog), WNT (wingless-type murine mammary tumor), or non-SHH/WNT subgroups.

Useful For Suggests clinical disorders or settings where the test may be helpful

Identification and differentiation of medulloblastomas

Interpretation Provides information to assist in interpretation of the test results

This test will be processed as a pathology consultation. An interpretation will be provided.

Clinical References Provides recommendations for further in-depth reading of a clinical nature

1. Ellison DW, Dalton J, Kocak M, et al: Medulloblastoma clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups. Acta Neuropathol 2011;121:381-396

2. Northcott PA, Korshunov A, Witt H, et al: Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 2011 Apr 10;29(11):1408-1414

3. Thompson MC, Fuller C, Hogg TL, et al: Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol 2006;24:1924-931