Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
The Fungitell Beta – D Glucan assay detects (1,3) – Beta-D-glucan from the following pathogens: Candida spp., Acremonium, Aspergillus spp., Coccidioides immitis, Fusarium spp., Histoplasma capsulatum, Trichosporon spp., Sporothrix schenckii, Saccharomyces cerevisiae, and Pneumocystis jiroveci.
The Fungitell Beta-D Glucan assay does not detect certain fungal species such as the genus Cryptococcus, which produces very low levels of (1,3) – Beta-D-glucan, nor the Zygomycetes, such as Absidia, Mucor, and Rhizopus, which are not known to produce (1,3) – Beta-D-glucan. Studies indicate Blastomyces dermatitidis is usually not detected due to little (1,3) – Beta-D-glucan produced in the yeast phase.
The performance characteristics of the Fungitell assay in BAL have been determined by Viracor-IBT Laboratories; there are no established criteria for the interpretation of Fungitell results from BAL fluid. Research studies have evaluated the use of the Fungitell assay in BAL in both immunocompromised patients (Mycopathologia (2013) 175:33-41) and acute eosinophilic pneumonia (Chest (2013) 123:1302-1307).
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
A reference range for specimens other than serum has not been established.