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Interpretive Handbook

Test 90158 :
Elastase, Pancreatic, Serum

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Serum Elastase, also called Pancreatopeptidase, is a protease present in

pancreatic secretion with the unique ability to rapidly hydrolyze elastin.

Elastin is a fibrillar protein found in connective tissue. Elastin forms the

elastic fibers found mostly in lungs and skin. Elastase is able to hydrolyze

denatured hemoglobin, casein, fibrin, albumin and denatured but not

native collagen. Elastase has been implicated in the pathogenesis of

pulmonary emphysema, atherosclerosis and in the vascular injury of

acute pancreatic necrosis. Elastase activity is inhibited by protease

inhibitors including a1-Anti-Trypsin, a1-anti-Chymotrypsin, anti-Thrombin

III, a2-Macroglobulin and b1-anti-Collagenase. Patients with thyroid

dysfunction have decreased Elastase activity. Serum pancreatic levels

quantify EL 1 for the diagnosis or exclusion of an acute pancreatitis or

an inflammatory episode of chronic pancreatitis or gallstone induced


Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Adult Reference Ranges:

Normal pancreatic exocrine function:

  Less than 3.5 ng/mL


No pediatric reference ranges available for this test.