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As an adjunct in the diagnosis of ehrlichiosis
In seroepidemiological surveys of the prevalence of the infection in certain populations
Serology for IgG may be negative during the acute phase of infection but a diagnostic titer usually appears by the third week after onset.
A positive immunofluorescence assay (titer > or =1:64) suggests current or previous infection. In general, the higher the titer, the more likely the patient has an active infection. Four-fold rises in titer also indicate active infection.
Previous episodes of ehrlichiosis may produce a positive serology although antibody levels decline significantly during the year following infection.
Performance characteristics have not been established for hemolyzed or lipemic specimens.
Fishbein DB, Dawson JE, Robinson LE: Human ehrlichiosis in the United States, 1985 to 1990. Ann Intern Med 1994;120:736-743