Interpretive Handbook

Test 80786 :
Epstein-Barr Virus (EBV) RNA Detection by In Situ Hybridization

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Epstein-Barr virus (EBV) plays a pathogenic role in a variety of disease states, including infectious mononucleosis, nasopharyngeal carcinoma, Burkitt lymphoma, B-cell lymphomas in patients with congenital or acquired immunodeficiency, and some cases of classical Hodgkin lymphoma.

Useful For Suggests clinical disorders or settings where the test may be helpful

Detection of Epstein-Barr virus encoded RNA (EBER) in the diagnosis of EBV-associated conditions

Interpretation Provides information to assist in interpretation of the test results

This test, when not accompanied by a pathology consultation request, will be answered as either positive or negative. If additional interpretation/analysis is needed, please request test 70012 / Pathology Consultation along with this test.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.


Clinical References Provides recommendations for further in-depth reading of a clinical nature

1. Wu TC, Mann RB, Epstein JI, et al: Abundant expression of EBER1 small nuclear RNA in nasopharyngeal carcinoma. A morphologically distinctive target for detection of Epstein-Barr virus in formalin-fixed paraffin-embedded carcinoma specimens. Am J Pathol 1991;138:1461-1469

2. Randhawa PS, Jaffe R, Demetris AJ, et al: The systemic distribution of Epstein-Barr virus genomes in fatal post-transplantation lymphoproliferative disorders. An in situ hybridization study. Am J Pathol 1991;138:1027-1033

3. Chang KL, Chen YY, Shibata D, Weiss LM: Description of an in situ hybridization methodology for detection of Epstein-Barr Virus RNA in paraffin-embedded tissues, with a survey of normal and neoplastic tissues. Diagn Mol Pathol 1992;1:246-255