Epstein-Barr Virus (EBV) RNA Detection by In Situ Hybridization
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Epstein-Barr virus (EBV) plays a pathogenic role in a variety of disease states, including infectious mononucleosis, nasopharyngeal carcinoma, Burkitt lymphoma, B-cell lymphomas in patients with congenital or acquired immunodeficiency, and some cases of classical Hodgkin lymphoma.
Detection of Epstein-Barr virus encoded RNA (EBER) in the diagnosis of EBV-associated conditions
This test, when not accompanied by a pathology consultation request, will be answered as either positive or negative. If additional interpretation or analysis is needed, request 70012 / Pathology Consultation along with this test.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
No significant cautionary statements
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Clinical References Provides recommendations for further in-depth reading of a clinical nature
1. Wu TC, Mann RB, Epstein JI, et al: Abundant expression of EBER1 small nuclear RNA in nasopharyngeal carcinoma. A morphologically distinctive target for detection of Epstein-Barr virus in formalin-fixed paraffin-embedded carcinoma specimens. Am J Pathol 1991;138:1461-1469
2. Randhawa PS, Jaffe R, Demetris AJ, et al: The systemic distribution of Epstein-Barr virus genomes in fatal post-transplantation lymphoproliferative disorders. An in situ hybridization study. Am J Pathol 1991;138:1027-1033
3. Chang KL, Chen YY, Shibata D, Weiss LM: Description of an in situ hybridization methodology for detection of Epstein-Barr Virus RNA in paraffin-embedded tissues, with a survey of normal and neoplastic tissues. Diagn Mol Pathol 1992;1:246-255