Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Endomyocardial biopsies may be indicated to evaluate a variety of cardiac disorders. The procedure is performed using a device inserted through the jugular, subclavian, or femoral vein.
-Cardiac allograft rejection
-Idiopathic chest pain
-Secondary heart disease (amyloidosis, sarcoidosis, hemochromatosis, storage diseases, and neoplastic diseases)
This request will be processed as a consultation. Appropriate stain(s) will be performed and a diagnostic interpretation provided.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Either wet tissue fixed in 10% neutral buffered formalin or Trump's solution or slides and paraffin blocks may be submitted.
Electron microscopy is generally only performed for the evaluation of adriamycin cardiotoxicity and storage diseases. For the evaluation of adriamycin cardiotoxicity, specimens should be fixed in glutaraldehyde or Trump's solution.
Clinical diagnosis must be submitted with the specimen.
Not useful for distinguishing between alcoholic cardiomyopathy and idiopathic dilated cardiomyopathy.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Abnormalities will be compared to reported reference values.
Clinical References Provides recommendations for further in-depth reading of a clinical nature
Edwards WD, Holmes DR Jr: Transvenous endomyocardial biopsy. In Mayo Clinic Practice of Cardiology: Fundamentals and Practice. 3rd edition. Edited by ER Giuliani, BJ Gersh, MD McGooh, et al. St. Louis, MO, Mosby-Yearbook, 1996, pp 672-688