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Crucial diagnostic information for the study of human disease may be provided by transmission and scanning electron microscopy. Often information of a confirmatory nature or of educational value to the clinician and pathologist can be obtained by this procedure.
In recent years, the technology involved in electron microscopy has progressed to the point where methods have become standardized and the instrumentation routine. The electron microscope is a fundamental tool in medical diagnostic and cellular pathobiological investigations, because it is at this instrument's level of resolution that most structural correlations with function and metabolism are visible.
Diagnosing medical disorders such as storage diseases, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and primary ciliary dyskinesia
The images and case histories are correlated and interpreted by a pathologist who is an expert in the field of the suspected diagnoses.
Results will be provided by telephone. If requested, representative images showing diagnostic features will be sent.
Certain factors are necessary for interpretation of electron microscopic images as follows:
-Optimal fixation of viable and representative tissue is imperative.
-Tumor biopsies must be accompanied by a history, hematoxylin and eosin-stained slides, and a paraffin block.
-The tissue submitted must have been viable at the time of fixation.
-Selection of tissue representative of the lesion is essential.
An interpretive report will be provided.
Damjanov I: Ultrastructural Pathology of Human Tumors. St. Albens, VT, Eden Press, Vol 1, 1979; Vol 2, 1980