Interpretive Handbook
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Test 505339:
Drug of Abuse, Phencyclidine Screen With GC-MS Confirmation, Urine
Clinical Information 
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Phencyclidine (PCP) is a drug of abuse. This compound affects diverse neural pathways and interacts with cholinergic, adrenergic, GABA-secreting, serotoninergic, opiate neuronal receptors, and gamma receptors. It has analgesic, anesthetic, and stimulatory effects, giving bizarre behavior, ranging from depression through catatonia, euphoria, violent rage, and hallucinations. Most fatalities result from its hypertensive effect.
Diagnosis of PCP usage depends on drug screen. PCP is excreted in the urine.
Useful For Suggests clinical disorders or settings where the test may be helpful
Detection of drug abuse involving PCP (angel dust or angel hair)
Interpretation Provides information to assist in interpretation of the test results
The presence of PCP in urine at concentrations >10 ng/mL is a strong indicator that the patient has used PCP.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Urine PCP levels may be undetectable at alkaline pH.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Negative
EMIT cutoff concentration: 25 ng/mL
Positives are reported with a quantitative GC-MS result.
Clinical References Provides recommendations for further in-depth reading of a clinical nature
Baselt RC: In Disposition of Toxic Drugs and Chemicals in Man, 5th edition. Chemical Toxicology Institute, Foster City, CA 2000
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