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Interpretive Handbook

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Test 9109:
CBC with Differential, Blood

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

RBCs, WBCs, and platelets are produced in the bone marrow and released into the peripheral blood. The primary function of the RBC is to deliver oxygen to tissues. WBCs are key components of the immune system. Platelets play a vital role in blood clotting.

 

Mean corpuscular volume (MCV) is a measure of the size of the average RBC. Anemias are characterized as microcytic (MCV<80), macrocytic (MCV>100), or normocytic. The red cell distribution width (RDW) is a measure of the degree of variation in RBC size (anisocytosis). RDW may be helpful in distinguishing between some anemias. For example, iron deficiency anemia is characterized by a high RDW, while thalassemia is characterized by a low RDW.

Useful For Suggests clinical disorders or settings where the test may be helpful

Screening tool to confirm a hematologic disorder

 

Establish or rule out a diagnosis

 

Detect an unsuspected hematologic disorder

 

Monitor effects of radiation or chemotherapy

 

These counts are used as clinical guides in the diagnosis and/or monitoring of many diseases.

Interpretation Provides information to assist in interpretation of the test results

Results outside of normal value ranges may reflect a primary disorder of the cell-producing organs or an underlying disease. Results should be interpreted in conjunction with the patient’s clinical picture and appropriate additional testing performed.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Questionable results are detected by in-house checking criteria based on quantitative and qualitative parameters.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

RED BLOOD CELL COUNT (RBC)

Males

Birth: 3.90-5.50 x 10(12)/L

1-7 days: 3.90-6.00 x 10(12)/L

8-14 days: 3.60-6.00 x 10(12)/L

15 days-1 month: 3.00-5.50  x 10(12)/L

2-5 months: 3.10-4.50 x 10(12)/L

6-11 months: 3.70-6.00 x 10(12)/L

1-2 years: 3.70-6.00 x 10(12)/L

2 years: 4.10-5.10 x 10(12)/L

3-5 years: 4.10-5.30 x 10(12)/L

6-11 years: 4.20-5.10 x 10(12)/L

12-15 years: 4.40-5.50 x 10(12)/L

Adults:  4.32-5.72 x 10(12)/L

Females

Birth:  3.90-5.50 x 10(12)/L

1-7 days: 3.90-6.00 x 10(12)/L

8-14 days: 3.60-6.00 x 10(12)/L

15 days-1 month:  3.00-5.50 x 10(12)/L  

2-5 months: 3.10-4.50 x 10(12)/L

6-11 months: 3.70-6.00x 10(12)/L

1-2 years: 3.70-6.00 x 10(12)/L

2 years: 4.10-5.10 x 10(12)/L  

3-5 years: 4.10-5.20 x 10(12)/L

6-11 years: 4.10-5.30 x 10(12)/L

12-15 years: 4.10-5.20 x 10(12)/L

Adults: 3.90-5.03 x 10(12)/L

 

HEMOGLOBIN

Males

Birth -7 days:  13.5-22.0 g/dL

8-14 days: 12.5-21.0 g/dL

15 days-1 month: 10.0-20.0 g/dL

2-5 months: 10.0-14.0 g/dL

6 months-2 years: 10.5-13.5 g/dL

2 years: 11.0-14.0 g/dL

3-5 years:11.0-14.5 g/dL

6-11 years: 12.0-14.0 g/dL

12-15 years: 12.8-16.0 g/dL

Adults: 13.5-17.5 g/dL

Females

Birth-7 days: 13.5-22.0 g/dL

8-14 days: 12.5-21.0 g/dL

15 days-1 month: 10.0-20.0 g/dL

2-5 months: 10.0-14.0 g/dL

6 months-2 years: 10.5-13.5 g/dL

2 years: 11.0-14.0 g/dL  

3-5 years: 11.8-14.7 g/dL

6-11 years: 12.0-14.5 g/dL

12-15 years: 12.2-14.8 g/dL

Adults: 12.0-15.5 g/dL

 

HEMATOCRIT

Males

Birth-7 days: 42.0-60.0%

8-14 days: 39.0-60.0%

15 days-1 month:  31.0-55.0%

2-5 months: 28.0-42.0%

6 months-1 year: 33.0-40.0%

2 years: 33.0-42.0%

3-5 years: 33.0-43.0%

6-11 years: 35.8-42.4%

12-15 years: 37.3-47.3%

Adults: 38.8-50.0%

Females

Birth-7 days: 42.0-60.0%

8-14 days: 39.0-60.0%

15 days-1 month: 31.0-55.0%  

2-5 months: 28.0-42.0%

6 months-1 year: 33.0-40.0%

2 years: 33.0-42.0%

3-5 years: 35.0-44.0%

6-11 years: 35.7-43.0%

12-15 years: 36.3-43.4%

Adults: 34.9-44.5%

 

MEAN CORPUSCULAR VOLUME (MCV)

Males

Birth:  98.0-120.0 fL

1-7 days: 88.0-120.0 fL

 8-14 days: 86.0-120.0 fL

15 days-1 month: 85.0-110.0 fL  

2-5 months: 77.0-110.0 fL

6 months-5 years: 74.0-89.0 fL

6-11 years: 76.5-90.6 fL

12-15 years: 81.4-91.9 fL

Adults: 81.2-95.1 fL

Females

Birth:   98.0-120.0 fL

1-7 days: 88.0-120.0 fL

8-14 days: 86.0-120.0 fL

15 days-1 month: 85.0-110.0 fL  

2-5 months: 77.0-110.0 fL

6 months-5 years: 74.0-89.0 fL

6-11 years: 78.5-90.4 fL

12-15 years: 79.9-92.3 fL

Adults: 81.6-98.3 fL

 

RED CELL DISTRIBUTION WIDTH (RDW)

Males

<2 years: not established  

2 years: 12.0-14.5%

3-5 years: 12.0-14.0%

6-11 years: 12.0-14.0%

12-15 years: 11.6-13.8%

Adults: 11.8-15.6%

Females

<2 years: not established

2 years: 12.0-14.5%

3-5 years: 12.0-14.0%

6-11 years: 11.6-13.4%

12-15 years: 11.2-13.5%

Adults: 11.9-15.5%

 

WHITE BLOOD CELL COUNT (WBC)

Males

Birth:  9.0-30.0 x 10(9)/L

1-7 days: 9.4-34.0 x 10(9)/L

8-14 days: 5.0-21.0 x 10(9)/L

15 days-1 month:  5.0-20.0 x 10(9)/L

2-5 months: 5.0-15.0 x 10(9)/L

6 months-2 years: 6.0-11.0 x 10(9)/L

2 years: 5.0-12.0 x 10(9)/L

3-5 years: 4.0-12.0 x 10(9)/L

6-11 years: 3.4-9.5 x 10(9)/L

12-15 years: 3.6-9.1 x 10(9)/L

Adults: 3.5-10.5 x 10(9)/L

Females

Birth:  9.0-30.0 x 10(9)/L

1-7 days: 9.4-34.0 x 10(9)/L

8-14 days: 5.0-21.0 x 10(9)/L

15 days-1 month: 5.0-20.0 x 10(9)/L

2-5 months: 5.0-15.0 x 10(9)/L

6 months-2 years: 6.0-11.0 x 10(9)/L

2 years: 5.0-12.0 x 10(9)/L

3-5 years: 4.0-12.0 x 10(9)/L

6-11 years: 3.4-10.8 x 10(9)/L

12-15 years: 4.1-8.9 x 10(9)/L

Adults: 3.5-10.5 x 10(9)/L

 

NEUTROPHILS

Birth:  9.00-26.00 x 10(9)/L

1-7 days: 1.50-10.00 x 10(9)/L

8-14 days: 1.00-9.50 x 10(9)/L

15 days-1 month: 1.00-9.00 x 10(9)/L

2-5 months: 1.00-8.50 x 10(9)/L

6 months–5 years: 1.50-8.50 x 10(9)/L

6-11 years: 1.50-8.50 x 10(9)/L

12-15 years: 1.80-8.00 x 10(9)/L

Adults: 1.70-7.00 x 10(9)/L

 

LYMPHOCYTES

Birth:  2.00-11.00 x 10(9)/L

1-7 days: 2.00-11.00 x 10(9)/L

8-14 days: 2.00-17.00 x 10(9)/L

15 days-1 month: 2.50-16.50 x 10(9)/L

2-5 months: 4.00-13.50 x 10(9)/L

6 months–11 months: 4.00-10.50 x 10(9)/L

1-5 years: 1.50-7.00 x 10(9)/L

6-11 years: 1.50-6.50 x 10(9)/L

12-15 years: 1.20-5.20 x 10(9)/L

Adults: 0.90-2.90 x 10(9)/L

 

MONOCYTES

Birth-14 days: 0.40-1.80 x 10(9)/L

15 days-11 months: 0.05-1.10 x 10(9)/L

1-15 years: 0.00-0.80 x 10(9)/L

Adults: 0.30-0.90 x 10(9)/L

 

EOSINOPHILS

Birth–5 months: 0.02-0.85 x 10(9)/L

6 months–11 months: 0.05-0.70 x 10(9)/L

1-5 years: 0.0-0.65 x 10(9)/L

6-15 years: 0.00-0.50 x 10(9)/L

Adults: 0.05-0.50 x 10(9)/L

 

BASOPHILS

Birth-5 months: 0.00-0.60 x 10(9)/L

6 months–16 years: 0.00-0.20 x 10(9)/L

> or =17 years: 0.00-0.30 x 10(9)/L

 

PLATELETS

Birth-5 months: 150-350  x 10(9)/L

> or =6 months: 150-450 x 10(9)/L

Clinical References Provides recommendations for further in-depth reading of a clinical nature

1. Johnson M, Samuels C, Jozsa N, Gorney K: Three-way evaluation of high-throughput hematology analyzers-Beckman Coulter LH750, Abbott Cell-Dyn 4000, and Sysmex XE2100. Lab Hematol 2002;8:230-238

2. Klee G: Decision rules for accelerated hematology laboratory investigation. University of Minnesota 1974;thesis (PhD)