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Interpretive Handbook

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Test 62756 :
CD103, Immunostain

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

CD103, also known as integrin alpha E, is an integrin subunit protein, which is widely expressed on T cells. CD103 is a useful diagnostic tool in the diagnosis of hairy cell leukemia.

Useful For Suggests clinical disorders or settings where the test may be helpful

Aids in the diagnosis of hairy cell leukemia and marginal zone lymphomas

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

This request will be processed as a consultation. An interpretation will be provided.

Clinical References Provides recommendations for further in-depth reading of a clinical nature

1. Morgan EA, Yu H, Pinkus JL, et al: Immunohistochemical Detection of Hairy Cell Leukemia in Paraffin Sections Using a Highly Effective CD103 Rabbit Monoclonal Antibody. Am J Clin Pathol 2013;139:220-230

2. Shao H, Calvo KR, Gronborg M, et al: Distinguishing hairy cell leukemia variant from hairy cell leukemia: Development and validation of diagnostic criteria. Leuk Res 2013;37:401-409

3. Abdel-Ghafar AA, El Din El Telbany MA, Mahmoud HM, et al: Immunophenotyping of chronic B-cell neoplasms: flow cytometry versus immunohistochemistry. Hematol Rep 2012;4(1):e3