Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
The transferrin receptor (CD71) is highly expressed on the surface of cells of the erythroid lineage and mediates the uptake of transferrin-iron complexes. Transferrin receptor expression levels are highest in early erythroid precursors through the intermediate normoblast phase, then expression decreases through the reticulocyte phase.
Assessment of erythroid lineage
This test will be processed as a pathology consultation. An interpretation will be provided.
Clinical References Provides recommendations for further in-depth reading of a clinical nature
1. Dong HY, Wilkes S, Yang H: CD71 is selectively and ubiquitously expressed at high levels in erythroid precursors of all maturation stages: A comparative immunochemical study with glycophorin A and hemoglobin A. Am J Surg Pathol 2011 May;35(5):723-732
2. Marsee DK, Pinkus GS, Yu H: CD71 (transferrin receptor): an effective marker for erythroid precursors in bone marrow biopsy specimens. Am J Clin Pathol 2010;134:429-435
3. Sokmensuer LK, Muftuoglu S, Asan E: Immunohistochemical analysis of CD71, CD98 and CD99 activation antigens in human palatine and nasopharyngeal tonsils. Saudi Med J 2005;26(3):385-389