Interpretive Handbook

Test 8608 :
Bromide, Blood

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Bromides are ingested principally as sedatives. They are used outside the United States to treat grand mal and focal epilepsy.


Bromide shares the same volume of distribution as chloride, competes with chloride for renal excretion, and has a blood half-life of 12 to 15 days.


Signs of acute toxicity include nausea, vomiting, and diarrhea. Manifestations of chronic toxicity can include lethargy, fatigue, irritability, loss of appetite, tachypnea, skin pigmentation, hallucinations, ataxia, and coma.

Useful For Suggests clinical disorders or settings where the test may be helpful

Assessing possible toxicity

Interpretation Provides information to assist in interpretation of the test results

Therapeutic concentration: 1,000-2,000 mcg/mL


Toxic concentration: > or =3,000 mcg/mL

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Therapeutic concentration: 1,000-2,000 mcg/mL

Toxic concentration: > or =3,000 mcg/mL


NIH Unit

Therapeutic concentration: 12.5-25.0 mmol/L

Toxic concentration: >27.5 mmol/L

Clinical References Provides recommendations for further in-depth reading of a clinical nature

Bowers GN Jr, Onoroski M: Hyperchloremia and the incidence of bromism in 1990 (editorial). Clin Chem 1990;36:1399-1403