Angiotensin I, Plasma
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Angiotensin I is a ten amino acid peptide formed by Renin cleavage of
Angiotensinogen (Renin Substrate). Angiotensin I has little biological
activity except that high levels can stimulate Catecholamine production.
It is metabolized to its biologically active byproduct Angiotensin II by
Angiotensin Converting Enzyme (ACE). The formation of Angiotensin I is
controlled by negative feedback of Angiotensin II and II on Renin
release and by Aldosterone concentration. Levels of Angiotensin I are
increased in many types of hypertension. Angiotensin I levels are used
to determine Renin activity. Angiotensin I is excreted directly into the
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Up to 25 pg/mL
This test was performed using a kit that has not been cleared or approved by the FDA and is designated as research use only. The analytic performance characteristics of this test have been determined by Inter Science Institute. This test is not intended for diagnosis or patient management decisions without confirmation by other medically established means.