17-Hydroxy Progesterone, Urine
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
17-Hydroxy Progesterone is a steroid derived primary from enzymatic
metabolism of Progesterone and 17-Hydroxy Pregnenolone. It is converted
enzymatically to Androstenedione and 11-Deoxycortisol. It is produced
in both the gonads and adrenal glands. It is excreted into the urine in
conjugated and unconjugated forms of 17-Hydroxy Progesterone and
as Pregnanetriol. This assay measures the total of the conjugated and
unconjugated forms. It is stimulated by ACTH and suppressed by
Dexamethasone. Levels of urine 17-Hydroxy Progesterone are greatly
increased in patients with Polycystic Ovarian Disease and Congenital
Adrenal Hyperplasia and show exaggerated responses to ACTH in
these cases. 17-Hydroxy Progesterone is the marker steroid for
determining cases of 21a-Hydroxylase Deficient Congenital Adrenal
Hyperplasia. Urine levels are frequently elevated in patients with
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Pediatric Reference Ranges:
Newborns and Infants: 3 days to 1 year: Up to 50 ng/24 hrs
Children: 1 - 8 years: Up to 300 ng/24 hrs
Adult Reference Ranges:
Male: Up to 2.0 ug/24 hrs.
Female: Up to 4.5 ug/24 hrs.