Test Catalog

Interpretive Handbook

Test 62746 :
Volatile Screen, Chain of Custody, Urine

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Urine provides a medium for easy screening for methanol, ethanol, isopropanol, and acetone.

 

Chain of custody is a record of the disposition of a specimen to document who collected it, who handled it, and who performed the analysis. When a specimen is submitted in this manner, analysis will be performed in such a way that it will withstand regular court scrutiny.

Useful For Suggests clinical disorders or settings where the test may be helpful

Detecting the presence of acetone, methanol, isopropanol, or ethanol in urine with subsequent quantitation

 

Chain of custody is required whenever the results of testing could be used in a court of law. Its purpose is to protect the rights of the individual contributing the specimen by demonstrating that it was under the control of personnel involved with testing the specimen at all times; this control implies that the opportunity for specimen tampering would be limited.

Interpretation Provides information to assist in interpretation of the test results

Methanol:

The presence of methanol indicates exposure which may result in intoxication, central nervous system (CNS) depression, and metabolic acidosis. Ingestion of methanol can be fatal if patients do not receive immediate medical treatment.

 

Ethanol:

The presence of ethanol indicates exposure which may result in intoxication, CNS depression, and metabolic acidosis.

 

Isopropanol:

The presence of isopropanol indicates exposure which may result in intoxication and CNS depression. Ingestion of isopropanol can be fatal if patients do not receive immediate medical treatment.

 

Acetone:

The presence of acetone may indicate exposure to acetone; it is also a metabolite of isopropanol and may be detected during ketoacidosis.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Quantitation of acetone, methanol, isopropanol, or ethanol in urine correlates poorly with degree of intoxication.

 

For best clinical correlation, VLTBX / Volatile Screen, Chain of Custody, Blood is suggested.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

METHANOL

Not detected (Positive results are quantitated.)

Cutoff concentration: 10 mg/dL

Toxic concentration: > or =10 mg/dL

 

ETHANOL

Not detected (Positive results are quantitated.)

Cutoff concentration: 10 mg/dL

 

ISOPROPANOL

Not detected (Positive results are quantitated.)

Cutoff concentration: 10 mg/dL

Toxic concentration: > or =10 mg/dL

 

ACETONE

Not detected (Positive results are quantitated.)

Cutoff concentration: 10 mg/dL

Toxic concentration: > or =10 mg/dL

Clinical References Provides recommendations for further in-depth reading of a clinical nature

1. Langman, LJ, Bechtel L, Holstege CP: Chapter 35: Clinical toxicology. In Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Edited by CA Burtis, ER Ashwood, DE Bruns. Philadelphia, PA, WB Saunders Co. 2011, pp 1109-1188

2. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 12th edition. Edited by LL Brunton, DK Blumenthal, N Murr, et al, New York, McGraw-Hill, 2011

3. Principles of Forensic Toxicology. Third edition, Edited by B Levine, Washington DC, AACC Press, 2010