Vitamin K1, Serum
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Vitamin K1 or phylloquinone is part of a group of similar fat soluble vitamins in which the 2-methyl-1,4-naphthoquinone ring is common. Phylloquinone is found in high amounts in leafy green vegetables and some fruits (avocado, kiwi). It is a required cofactor involved in the gamma-carboxylation of glutamate residues of several proteins. Most notably, the inactive forms of the coagulation factors prothrombin (factor II), factors VII, IX, and X and protein S and protein C are converted to their active forms by the transformation of glutamate residues to gamma-carboxyglutamic acid (Gla). Other proteins such as those involved in bone metabolism, cell growth, and apoptosis also undergo this Gla transformation. Measurement of vitamin K1 (phylloquinone) in fasting serum is a strong indicator of dietary intake and status.
Assessment of circulating vitamin K1 concentration
Low vitamin K1 concentrations in the serum are indicative of insufficiency and poor vitamin K1 status.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Testing of nonfasting specimens or the use of vitamin K1 supplementation can result in elevated serum vitamin K1 concentrations.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
> or =18 years: 0.10-2.20 ng/mL
<18 years: not established
Clinical References Provides recommendations for further in-depth reading of a clinical nature
1. Vermeer C: Vitamin K: the effect on health beyond coagulation-an overview. Food Nutr Res 2012;56:5329
2. Lippi G, Franchini M: Vitamin K in neonates: facts and myths. Blood Transfus 2011;9:4-9
3. Greer FR: Vitamin K the basics-What’s new? Early Hum Dev 2010;86:S43-S47