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Interpretive Handbook

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Test 62180 :
Thyroid Transcription Factor (8G7G3/1), Immunostain

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Thyroid transcription factor 1 is a nuclear protein expressed in thyroid follicular cells, type II pneumocytes, and a subset of bronchial cells. Given its relative specificity for cells of thyroid or lung origin, this immunostain is often included in a panel to identify the primary site for carcinomas of unknown origin.

Useful For Suggests clinical disorders or settings where the test may be helpful

Identification of thyroid or lung cells as the primary tumor site in carcinomas of unknown origin

Interpretation Provides information to assist in interpretation of the test results

This test will be processed as a pathology consultation. An interpretation will be provided.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

This test is not an orderable test. Order 70012 / Pathology Consultation. The consultant will determine the need for special stains.


This request will be processed as a consultation. An interpretive report will be provided.

Clinical References Provides recommendations for further in-depth reading of a clinical nature

1. Comperat E, Zhang F, Perrotin C, et al: Variable sensitivity and specificity of TTF-1 antibodies in lung metastatic adenocarcinoma of colorectal origin. Mod Pathol 2005;18:1371-1376

2. Penman D, Downie I, Roberts F: Positive immunostaining for thyroid transcription factor-1 in primary and metastatic colonic adenocarcinoma: a note of caution. J Clin Pathol 2006;59:663-664

3. Katoh R, Kawaoi A, Miyagi E, et al: Thyroid Transcription Factor-1 in Normal, Hyperplastic, and Neoplastic Follicular Thyroid Cells Examined by Immunohistochemistry and Nonradioactive In Situ Hybridization. Mod Pathol 2000;13(5):570-576