Test Catalog

Interpretive Handbook

Test 60590 :
T- and B-Cell Quantitation and Lymphocyte Proliferation to Antigens and Mitogens Panel

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

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Useful For Suggests clinical disorders or settings where the test may be helpful

Assessing antigen-specific T-cell responses, global T-cell function, and quantitating lymphocyte subsets in a single orderable test.


This panel is most helpful when evaluating patients with immunodeficiencies, where quantitative decreases in T cells can lead to reduced functional antigen and/or mitogen responses.


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Interpretation Provides information to assist in interpretation of the test results

Since the presence of lymphopenia, particularly in the T-cell compartment, can reduce the magnitude of the proliferative response to both mitogens and antigens, it is helpful to perform simultaneous numerical evaluation of lymphocyte subsets to aid in interpretation of the functional (proliferation) data.


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Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

There is no clinical utility to assessing antigen responses in infants less than 3 months old due to limited antigen exposure and vaccination. The only exception would be infants who develop Candidiasis prior to 3 months of age. This test is not intended for assessment of maternal engraftment.


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Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

The appropriate age-related reference values will be provided on the report.

Clinical References Provides recommendations for further in-depth reading of a clinical nature

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