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Interpretive Handbook

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Test 8243 :
Secobarbital, Serum

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Secobarbital is a short-acting barbiturate with hypnotic properties used as a preanesthetic agent and in the short-term treatment of insomnia.(1,2)

 

Secobarbital is administered orally. The duration of its hypnotic effect is about 3 to 4 hours. The drug distributes throughout the body, with a volume of distribution (Vd) of 1.6 to 1.9 L/kg, and about 46% to 70% of a dose is bound to plasma proteins. Metabolism takes place in the liver primarily via hepatic microsomal enzymes. Secobarbital's half-life is about 15 to 40 hours (mean: 28 hours).(2,3)

Useful For Suggests clinical disorders or settings where the test may be helpful

Monitoring secobarbital therapy

Interpretation Provides information to assist in interpretation of the test results

Therapeutic concentration: 1.0 to 2.0 mcg/mL

 

Toxic concentration: >5.0 mcg/mL

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

The concentration at which toxicity occurs varies; results should be interpreted in light of the clinical situation.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Therapeutic concentration: 1.0-2.0 mcg/mL

Toxic concentration: >5.0 mcg/mL

Concentration at which toxicity occurs varies and should be interpreted in light of clinical situation.

Clinical References Provides recommendations for further in-depth reading of a clinical nature

1. Goodman and Gilman's: The Pharmacological Basis of Therapeutics. 10th edition. New York, McGraw-Hill Book Company, 2001

2. Teitz Textbook of Clinical Chemistry and Molecular Diagnostics. Fourth edition. Edited by CA Burtis, ER Ashwood, DE Bruns. St. Louis, MO, Elsevier Saunders, 2006, p 1091

3. Disposition of Toxic Drugs and Chemicals in Man. Seventh edition. Edited by RC Baselt. Foster City, CA, Biomedical Publications, 2004, p 1254


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