Interpretive Handbook

Test 61011 :
Sex Chromosome Determination, FISH, Tissue

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Genotypically normal females possess 2 X chromosomes; genotypically normal males possess 1 X chromosome and 1 Y chromosome. Determining the sex chromosome complement in a tissue specimen can be used to:

-Identify opposite sex-donor cells post-transplant

-Help resolve cases of suspected sample mix-up

Useful For Suggests clinical disorders or settings where the test may be helpful

Identifying the sex chromosome complement in paraffin-embedded tissues

Interpretation Provides information to assist in interpretation of the test results

An interpretive report is provided.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

This test is not approved by the FDA and it is best used as an adjunct to existing clinical and pathologic information.


For testing of bone marrow samples from patients who have undergone an opposite sex transplant, order FBMT / XX/XY in Opposite Sex Bone Marrow Transplantation, FISH.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

An interpretive report will be provided.

Clinical References Provides recommendations for further in-depth reading of a clinical nature

1. Nakhleh RE, Zarbo RJ: Surgical pathology specimen identification and accessioning: A College of American Pathologists Q-Probes study of 1,004,115 cases from 417 institutions. Arch Pathol Lab Med 1996;120:227-233

2. Riopel MA, Yu IT, Hruban RH, et al: Whose tumor is this: FISHing for the answer. Mod Pathol 1995;8:456-457

3. Valenstein PN, Raab SS, Walsh MK: Identification Errors Involving Clinical Laboratories: A College of American Pathologists Q-Probes Study of Patient and Specimen Identification Errors at 120 Institutions. Arch Pathol Lab Med 2006;130:1106-1113