Interpretive Handbook

The Mayo Division of Anatomic Pathology is staffed by pathologists whose special interests cover the entirety of surgical pathology. Because of the volume of specimens, ranging from common to rare entities, the depth of experience is great.

For many years, Surgical Pathology has provided consultation service on difficult diagnostic problems. The histologic specimens are usually sent by a referring pathologist to one of the surgical pathologists who is an expert in the given area. Slides received in Mayo Medical Laboratories are reviewed by a surgical pathologist and, when necessary, shared with a pathologist whose area of special interest encompasses the problem. Emphasis is placed on prompt and accurate replies. Stained slides and blocks received are reviewed in conjunction with the supplied clinical history, laboratory findings, and pathologist's report. If additional special stains are needed, they are made and included in the interpretive process by the consulting pathologist. In some cases, electron microscopy and other procedures are utilized as required.

Obtaining a rapid, expert second opinion

Obtaining special studies not available locally

In products of conception, differentiating between complete moles and spontaneous abortion

The histologic slides, special stains, and history along with the primary pathologist's report and questions are correlated by a pathologist who has expertise in the suspected diagnosis. A verbal and written report is issued.

Molar Pregnancy Evaluation:

The p57 immunostain stains for proteins derived from the maternal allele of the p57 gene, also known as CDKN1C or Kip2. Because complete moles are entirely paternally-derived, they do not stain positive for p57. Conversely, tissue from spontaneous abortions show positive p57 staining.

This test is not to be used to obtain a primary diagnosis. Primary testing should be performed by a local pathology service and Mayo will render a second opinion if requested.

Appropriate tissue sampling and fixation is required in order to make a diagnosis on routine stains and on special stains or studies which may be required.

The referring pathologist's name and phone number are essential.

This request will be processed as a consultation. An interpretation will be provided. Second opinion regarding diagnosis will be rendered by staff pathologists in consultation with colleagues who have expertise in the appropriate subspecialty areas. Appropriate stain(s) will be performed and charged separately.

Note: This test is not to be used to obtain a primary diagnosis. Primary testing should be performed by a local pathology service; Mayo Clinic will render a second opinion, if requested.

Not applicable