Renal Biopsy, Immunohistology
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Kidney biopsy has proven to be of value in the clinical evaluation and management of patients with undiagnosed kidney disease. The clinical setting may include acute renal failure, nephrotic syndrome, asymptomatic proteinuria and hematuria. Kidney diseases in the setting of a systemic disease are often diagnosed on kidney biopsy.
Biopsy of the transplanted kidney is important in the determination of the presence of acute rejection, infection, or recurrent disease.
Optimal interpretation of a kidney biopsy requires integration of clinical and laboratory results with light microscopic, immunofluorescent histology, and electron microscopy findings.
Immunofluorescent histology is necessary in the diagnosis of immune complex mediated disease such and IgA nephropathy, membranous nephropathy, and post-infectious glomerulonephritis; for evaluation of light-chain related disease such as amyloidosis, light-chain deposition disease, and light-chain cast nephropathy, and other immune-mediated diseases such as Goodpasture's disease and lupus nephritis.
The evaluation of patients with undiagnosed kidney disease
Following the course of therapy or progression of disease
Diagnosing disease cause by immune mechanisms
The evaluation of kidney and/or lung specimens for Goodpasture’s disease
A written report is issued upon completion of immunohistologic examination. If material is also submitted for light microscopy, the immunohistologic report will be incorporated with the light microscopic findings and a written report will be issued.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Accurate and timely interpretation of a kidney biopsy requires integration of light microscopic, immunofluorescent histology, and electron microscopic findings with clinical and laboratory data.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
An interpretive report will be provided.
Clinical References Provides recommendations for further in-depth reading of a clinical nature
Velosa JA, Holley KE: Pathology and immunopathology of renal diseases. In Renal Function Tests: Clinical Laboratory Procedures and Disorders. Edited by CG Duarte. Boston, MA, Little, Brown, and Company, 1980, pp 347-385