Interpretive Handbook

Progesterone is a Progestin produced primarily from enzymatic

metabolism of Pregnenolone. It is enzymatically converted to 17-Hydroxy

Progesterone and 11-Deoxycorticosterone. It is secreted by both the

gonads and the adrenal glands. It is bound to Cortisol Binding Globulin

and Albumin, but a small percentage is present in the "Free" bioactive

form. It is excreted into the urine as its conjugated and unconjugated

forms and as Pregnanediol (conjugated and unconjugated). This assay

measures the conjugated and unconjugated forms of Progesterone.

Progesterone is responsible for cellular changes in the cervix, vagina,

and uterus. Levels are lowest in the follicular phase and increase rapidly

following the luteal surge. Progesterone increases greatly during pregnancy.

Measurement of Urine Progesterone can be useful to monitor fertility,

corpus luteum function, endometrial development, and be helpful in

in-vitro fertilization patients yielding an integrated look of Progesterone

activity over a 24-hour period.

Adult Males:  up to 0.5 ug/24 hours

Adult Females:  up to 2.8 ug/24 hours

This test was performed using a kit that has been approved by the

FDA for an alternate matrix. The analytic performance characteristics

of this test for the submitted matrix have been determined by

Inter Science Institute.

Test Performed By:  Inter Science Inst

                                        944 West Hyde Park

                                        Inglewood, CA  90302