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Phencyclidine (PCP) is a drug of abuse. This compound affects diverse neural pathways and interacts with cholinergic, adrenergic, GABA-secreting, serotoninergic, opiate neuronal receptors, and gamma receptors. It has analgesic, anesthetic, and stimulatory effects, giving bizarre behavior, ranging from depression through catatonia, euphoria, violent rage, and hallucinations. Most fatalities result from its hypertensive effect.
Diagnosis of PCP usage depends on drug screen. PCP is excreted in the urine.
Detection of drug abuse involving phencyclidine (angel dust or angel hair)
The presence of phencyclidine (PCP) in urine at concentrations >10 ng/mL is a strong indicator that the patient has used PCP.
Urine phencyclidine (PCP) may be undetectable at alkaline pH. Urine pH must, therefore, always be recorded.
For chain-of-custody information, see PCPX / Phencyclidine Confirmation, Chain of Custody, Urine.
Phencyclidine by GC-MS: <10 ng/mL
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