Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Neurotensin is a 13 amino acid peptide produced primarily by endocrine
cells of the ileal mucosa. Physiological actions of Neurotensin include
hypertension, vasodilation, hyperglycemia, and inhibition of gastric motility.
Its C-terminus is similar to Angiotensin I. It is a potent analgesic affecting
hypothermia, muscle relaxation, and decreased motor activity. Pancreatic
Polypeptide secretion is strongly stimulated by Neurotensin. Neurotensin
appears to cause the release of Luteinizing Hormone-Releasing Hormone
and Corticotropin Releasing Hormone effecting the release of Luteinizing
Hormone, Follicle Stimulating Hormone, and ACTH but not Thyroid
Stimulating Hormone or Growth Hormone. Neurotensin also stimulates
pancreatic bicarbonate and intestinal secretion. Neurotensin levels are
stimulated by food and Bombesin. Elevated levels have been found in
pancreatic endocrine tumors, Oat Cell, Squamous, and Adeno Carcinomas.
Elevated levels have been found to cause watery diarrhea.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
No significant cautionary statements
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Test Performed By: Inter Science Inst
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