Interpretive Handbook

Test 62577 :
Human Papillomavirus (HPV), Low-Risk, DNA In Situ Hybridization

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Human papillomavirus infections with low-risk genotypes (6, 11) can cause benign hyperplasia such as condylomas and papillomas.

Useful For Suggests clinical disorders or settings where the test may be helpful

Detection of human papillomavirus (HPV) DNA from low-risk genotypes (6, 11)

Interpretation Provides information to assist in interpretation of the test results

This test, when not accompanied by a pathology consultation request, will be answered as either positive or negative. If additional interpretation/analysis is needed, please request test 70012 / Pathology Consultation along with this test.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.


Clinical References Provides recommendations for further in-depth reading of a clinical nature

1. Kelesidis T, Aish L, Steller MA, et al: Human Papillomavirus (HPV) Detection Using In Situ Hybridization in Histologic Samples. Am J Clin Pathol 2011;136:119-127

2. Lee WT, Tubbs RR, Teker AM, et al: Use of in situ hybridization to detect human papillomavirus in head and neck squamous cell carcinoma patients without a history of alcohol or tobacco use. Arch Pathol Lab Med 2008;132:1653-1656

3. Birner P, Bachtiary B, Dreier B, et al: Signal-amplified colorimetric in situ hybridization for assessment of human papillomavirus infection in cervical lesions. Mod Pathol 2001;14(7):702-709