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Interpretive Handbook

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Test 90165:
Gonadotropin Releasing Hormone (Gn-RH)

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Gonadotropin-Releasing Hormone (Gn-RH), also known as

Luteinizing Hormone-Releasing Hormone (LH-RH), is a decapeptide

secreted pulsatily from the hypothalamus. It stimulates the release of

the Gonadotropins - Luteinizing Hormone and Follicle Stimulating

Hormone - exerting a stronger effect on Luteinizing Hormone.

Testosterone and Estradiol, whose release is stimulated by the

Gonadotropins, exert a negative feedback control on LH-RH both at

the hypothalamic site and by decreasing pituitary receptor binding.

LH-RH levels are low in patients with hypothalamic hypogonadism

differentiating them from the high levels usually found in primary

hypopituitary hypogonadism. Accentuation of the LH-RH pulse

occurs at the onset of puberty triggering the release of LH and FSH

required in pubertal development. LH-RH is stimulated by Epinephrine

and suppressed by Dopamine and opiates. LH-RH and some of its

agonists are frequently used to induce ovulation.  

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Adult Reference Range(s):

 

Males:  4.0-8.0 pg/mL

Females:  2.0-10.0 pg/mL

 

Test Performed by: Inter Science Institute

                                       944 West Hype Park

                                        Inglewood, CA 90302